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Understanding the origin of this mutation will inform medical genetics.We sequenced the genomes of 102 individuals from Antioquia, Colombia.The age and geographic origin of E280A are consistent with a single founder dating from the time of the Spanish Conquistadors who began colonizing Colombia during the early 16th century.Translational Genomics Group, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia A glutamic acid to alanine mutation at codon 280 (E280A) in the presenilin-1 gene (PSEN1) causing early-onset familial Alzheimer’s disease (EOFAD) at a mean age of 49 years [1] and displaying a fully penetrant autosomal dominant transmission was first discovered in a kindred in the state of Antioquia, Colombia [2,3].Subsequently, a large extended kindred from the same region with over 5000 members was identified and described [4].All affected individuals have the same mutation, present the same phenotype, come from the same geographical region and share common last names.

In this study, we investigate a large sample of subjects from this extended kindred through whole-genome sequencing.Wonpy had only this month launched into beta, just before reaching out to Co Founders Lab to discuss a co-marketing agreement.“But it was obvious very quickly that there was a great match,” says Brimen, “and that as co-founders, Shahab [Kaviani, CEO of Co Founders Lab] and I would be a great team.” Brimen explains that the tech he had been developing was related to better matching two potential partners, before they had a chance to meet in person. He claims that during the private beta, Wonpy had generated statistically relevant data that correctly anticipated that personal “click” between two founders – something which is still somewhat difficult to do online.(It has raised 0,000 by soliciting via Rock The Post).This is not the first acquisition for Co Founders Lab.Startup Weekends are 54-hour events designed to provide superior experiential education for technical and non-technical entrepreneurs.

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