These missions bring European culture to the indigenous peoples of California, but also enable a serious decline of from one-third to one-half of the indigenous population there during the Mission period.
Two Franciscan priests lead the Domínguez–Escalante expedition west from Santa Fe in an attempt to find an overland route to the Spanish Catholic mission in Monterey.
Santa Fe is formally repossessed by the Spanish after Diego de Vargas negotiates a peace with the Pueblo Indians.
The following six years witness a difficult reinstatement of Spanish and Franciscan rule over the Pueblos, including another revolt in 1696, which is successfully countered by De Vargas and his forces.
Spanish conquistador Francisco Vázquez de Coronado embarks on an expedition into the unexplored territory north of colonized Mexico to search for the fabled Seven Cities of Gold.
The voyage lasts more than two years, during which Coronado travels through much of the American Southwest and as far north as present-day Kansas.
Later in the century, the pass will be used by half a million westward migrants as part of the main route of several emigrant trails.
Congress passes the Missouri Compromise, prohibiting slavery in the unorganized territory north of 36.5° latitude and west of the Mississippi River, except within the boundaries of the proposed state of Missouri, while permitting the admission of Maine as a free state.
Events listed below are notable developments for the region as a whole, not just for a particular state or smaller subdivision of the region; as historians Hine and Faragher put it, they "tell the story of the creation and defense of communities, the use of the lands, the development of markets, and the formation of states....
Spanish Franciscans, led by friar Junípero Serra, establish Mission San Diego de Alcalá in Las Californias.
By 1823, the missionaries successfully plant a series of 20 more missions along the coast of what becomes the Spanish province of Alta California.
This timeline of the American Old West is a chronologically ordered list of events significant to the development of the American West as a region of the United States prior to 1912.
The term "American Old West" refers to a vast geographical area and lengthy time period of imprecise boundaries, and historians' definitions vary.
Lewis and Clark sight the Pacific Ocean for the first time, near the mouth of the Columbia River.